110 Neurological adverse events to voriconazole: Evidence for therapeutic drug monitoring
نویسندگان
چکیده
منابع مشابه
Voriconazole therapeutic drug monitoring: retrospective cohort study of the relationship to clinical outcomes and adverse events
BACKGROUND Voriconazole is approved for treatment of invasive aspergillosis and other invasive fungal infections, but the role for therapeutic drug monitoring (TDM) is not clear. METHODS We performed a retrospective cohort study of patients at the University of Washington Medical Center and Fred Hutchinson Cancer Research Center from 2007-2009. We compared the effect of therapeutic levels on ...
متن کاملVoriconazole therapeutic drug monitoring.
We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P<0.025) between disease progression and drug concentration was detected. Favorable responses were observed in 10/10 patients with concentrations above 2.05 microg/ml, while disease progressed in 44% (n=18) of patients with concentrations below 2.05 microg/ml.
متن کاملVoriconazole Pharmacokinetics and Therapeutic Drug Monitoring : A Multi - Center Study
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiol...
متن کاملVoriconazole Pharmacokinetics and Therapeutic Drug Monitoring : A Multi
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiol...
متن کاملSuccessful management of voriconazole-associated hyponatremia with therapeutic drug monitoring.
Voriconazole is a broad-spectrum triazole antifungal agent and the first-choice therapy for invasive aspergillosis (IA) (1). Although voriconazole is generally well tolerated, anecdotal case reports have described unexpected severe adverse events related to voriconazole, such as hyponatremia, which potentially could result in death (2–4). We report a case of successful voriconazole treatment of...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2006
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(06)80107-4